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KMID : 0191120060210050871
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Journal of Korean Medical Science
2006 Volume.21 No. 5 p.871 ~ p.876
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Expression of Cyclooxygenase-2, p53 and Ki-67 in Gastric Cancer
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Joo Young-Eun
Rew Jong-Sun
Park Chang-Soo
Kim Sei-Jong
Chung Ik-Joo
Park Young-Kyu
Koh Yang-Seok
Lee Jae-Hyuk
Park Chang-Hwan
Lee Wan-Sik
Kim Hyun-Soo
Choi Sung-Kyu
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Abstract
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It has been reported that p53 mutation may contribute to upregulate cyclooxygenase (COX)-2 expression that is observed in malignant tissues. These molecules are involved in carcinogenesis by affecting tumor cell proliferation. The aim of this study was to examine the relationship between COX-2 or p53 expression and clinico-pathological characteristics including tumor cell proliferation in gastric cancer. COX-2 and p53 expressions were investigated with immunostaining, in tissue specimens obtained from 119 patients who underwent surgery for gastric cancer. The Ki-67 labeling index (LI) was counted by Ki-67 immunostaining. COX-2 and p53 expressions correlated significantly with depth of tumor invasion. However, there was no association between COX-2 or p53 expression and survival. p53 expression did not correlate with COX-2 expression. There was no significant difference in various clinicopathological variables between Ki-67 LI subgroups. The mean Ki-67 LI value of COX-2 positive tumors was significantly higher than that of negative tumors. The mean Ki-67 LI value of p53 positive tumors was not significantly higher than that of negative tumors. The mean Ki-67 LI value of both COX-2 and p53 positive tumors was significantly higher than that of both negative tumors. These results imply that COX-2 expression is associated with tumor cell proliferation of gastric cancer.
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KEYWORD
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Cyclooxygenase 2, Tumor Suppressor Protein p53, Cell Proliferation, Stomach Neoplasms, Immunohistochemistry
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